MTERF4 Antibody, HRP conjugated

Code CSB-PA800224LB01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) MTERF4 Polyclonal antibody
Uniprot No.
Target Names
MTERF4
Alternative Names
FLJ16261 antibody; HSPC096 antibody; MGC61716 antibody; MTER2_HUMAN antibody; MTERF domain containing 2 antibody; mTERF domain-containing protein 2 antibody; Mterfd2 antibody; OTTHUMP00000200479 antibody; OTTHUMP00000200519 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Transcription termination factor 4, mitochondrial protein (45-87AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
HRP
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Regulator of mitochondrial ribosome biogenesis and translation. Binds to mitochondrial ribosomal RNAs 16S, 12S and 7S and targets NSUN4 RNA methyltransferase to the mitochondrial large ribosomal subunit (39S).
Gene References into Functions
  1. The overexpression of MTERF4 induced a significant increase in the levels of APP protein and secreted Abeta 42 in HEK293-APPswe cells compared with control cells these results suggest that MTERF4 promotes the amyloidogenic processing of APP by inhibiting ADAM10 in HEK293-APPswe cells; therefore, MTERF4 may play an important role in the pathogenesis of Alzheimer's disease. PMID: 27894840
  2. analysis of the 3D crystal structure of the human MTERF4-NSUN4 complex PMID: 22949673
Subcellular Location
Mitochondrion.
Protein Families
MTERF family
Database Links

HGNC: 28785

OMIM: 615393

KEGG: hsa:130916

STRING: 9606.ENSP00000241527

UniGene: Hs.159556

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